DNA Testing

Beeblebrox Sphynx DNA tests all breeding cats in and/or leaving our cattery.  The DNA tests performed by Texas A&M University evaluates DNA for parentage markers, diseases and physical attritbutes.

We feel that in order to work towards the betterment of the sphynx breed, it is critical to ensure that cats with genetic abnormalities do not reproduce.

DNA Testing Disease Profiles

 

MPS1 - Mucopolysaccharidosis (SEVERE form).
The mucopolysaccharidoses (MPS)1 is a group of lysosomal storage disorders that involve the deficiency of specific enzymes required for the degradation of glycosaminoglycans. The disease is characterized by the lysosomal accumulation and urinary excretion of glycosaminoglycan dermatan sulfate . The clinical phenotype or appearance of MPS VI patients ranges from severe to relatively mild. The severe phenotype is characterized by growth retardation, coarse facial features, joint stiffness, corneal clouding, skeletal deformities, organ, and soft tissue involvement. As a result of DS storage in the heart valve and lung, the normal function of these organs is often compromised, leading to early death in affected individuals. If MPS1 or MPS7 results show +/+ or +/-, they would not be part of our breeding program. 

MPSM - Mucopolysaccharidosis MILD form.
This is the mild form of MPS1 (see above). If MPSM results show +/+ or +/-, they would not be part of our breeding program.

PKD - Polycystic Kidney Disease
This disease causes kidney failure in affected animals. If PKD results show +/+ or +/-, they would not be part of our breeding program.

PRA - Progressive Retinal Atrophy
This is a disease that causes the retina in the back of the eye to degenerate resulting in poor vision and even blindness. If PRA results show +/+ or +/-, they would not be part of our breeding program.

BLDAB - B Blood Group
This test determines the B blood type in cats. Being highly antigenic, it can be the cause of transfusion reactions, and neonatal isoerythrolysis (destruction of red blood cells) when a Type B cat is bred to a Type A cat. Type AB is very rare, but can occur. It usually does not cause reactions.  If BLDAB results show +/-, we would plan breeding accordingly with the goal of breeding the "B" out of the lines (i.e. use only an -/- partner).  If BLDAB results show +/+, we would have to or decide if the associated cat should be removed from our program or efforts made to carefully breed the incompatible blood type out of our lines.


DNA Testing Physical Profiles


ALBIN - Albino Coloration

CINNAM - Cinnamon coloration

Point1 - Siamese points

Point 2 - Burmese color shading

CHOC2 - Chocolate coloration

DILUT - Dilute coloration 
This is a dilution that affects both types of melanin and results in a visual color change of black to blue, red to cream color, chocolate to lilac/lavender. This does not include dilute modifier markers.

AGOUTI - Black coloration 
This is a recessively inherited black color found as a deletion in the agouti gene.

LonghairX - Irrelevant in sphynx.